Sirindhorn National Medical Rehabilitation Institute (SNMRI) was found in 1988. It was established with cooperation between Saijaithai foundation and the National Rehabilitation Centre for the Disabled, Japan. SNMRC is a technical division of the Department of Medical Services, Ministry of Public Health. At the beginning, the centre mainly provided technical support. There were 12 personnel. The temporary office was at the building of Institute of Dentistry. Name of the centre was given by Her Royal Highness Princess Maha Chakri Sirindhorn in year 1991.
Since 1994, SNMRI has moved to operate at the new buildings and rehabilitation services for out-patients have been providing. The 30 beds in-patient services started in year 1995, and increased to 48 beds in 1996. The grand opening ceremony was in 2000.